清末民初,佛山武学宗师黄飞鸿因噩梦预感女记者莫十三遇险,携弟子前往古云村(cūn )寻(xún )人(rén )。村(cūn )中(zhōng )蜈蚣教借蛊术胁迫村民献祭孩童,莫十三探查真相时被擒,身中噬魂蛊。黄飞鸿闯祭坛救人,因不忍伤及被蛊惑的村民反中蛊毒,幸得卧底蜈蚣教的(de )鬼(guǐ )脚(jiǎo )七(qī )暗(àn )中(zhōng )相(xiàng )助(zhù )。众(zhòng )人(rén )合(hé )力(lì )破(pò )除(chú )水源蛊毒,救治村民,鬼脚七伤愈拜师。巫师自焚后,线索指向广州东瀛会馆。黄飞鸿潜入会馆救出被掳孩童,对决主(zhǔ )事(shì )服(fú )部(bù )一郎,得知幕后黑手为西洋吸血鬼麦克罗。麦克罗散播疫毒祸乱羊城,以莫十三性命相要挟。黄飞鸿于绝境中融合腿法,悟出佛山无影脚,击杀麦克罗(luó )。蛊(gǔ )毒(dú )尽(jìn )解(jiě ),百(bǎi )姓(xìng )恢(huī )复(fù )神(shén )智(zhì ),广(guǎng )州(zhōu )重(chóng )归太平,宝芝林重回烟火日常。